Psilocybin Study Offers Breakthrough For Major Depressive Disorder

Major Depressive Disorder (MDD) is a known serious mental health condition affecting millions worldwide. Researchers found that psilocybin, a compound found in certain mushrooms that can be accessed at a “mushroom dispensary near me,” has shown promising results in treating MDD. Only acquire psilocybin products from reliable dispensaries such as Zoomies Canada. 

What are the Studies’ Findings?

In a recent study on psilocybin therapy for treatment-resistant depression (TRD), researchers found promising results. They conducted the largest study of its kind, involving 233 TRD patients.

Participants were given different doses of COMP360 psilocybin and support from therapists. After receiving a single dose, about 30% of TRD patients were in remission three weeks later, specifically those with the 25 mg dose. This showed a significant improvement in depression symptoms compared to those who had a lower dose.

Those who received the 25 mg dose also had double the sustained response at week 12 compared to the lower dose group. The therapy was normally well-tolerated, with common side effects like headaches, nausea, and dizziness.


Researchers Findings
Scott Aaronson, MD., a Principal Investigator Mentioned that millions of people around the world suffer from TRD and haven’t found relief from existing therapies. He highlighted that the study showed substantial improvement in depression symptoms for many patients, lasting up to three months.
Guy Goodwin, MD, Chief Medical Officer at COMPASS Pathways He emphasized recognizing COMP360 psilocybin as a potential new treatment option.

Alternatives to Relieve Depression – Trial

Psilocybin is a chemical in certain types of mushrooms. Some early studies suggested it might help with depression, especially in people with life-threatening illnesses like cancer. Other studies looked at psilocybin for regular depression and found it might help there too.

But one thing is true: treating depression that doesn’t respond to regular treatments is hard. A study called the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial showed this. 

The study found that fewer people got better with each new antidepressant they tried. For example, about 37% of people got better after the first treatment, but only about 30% did after the second treatment, and even fewer after that.

When someone doesn’t get better after trying two different treatments, it’s often called treatment-resistant depression. People with this type of depression usually have more severe symptoms, struggle for longer, and may have other problems like physical illness or thoughts of suicide.

Psilocybin and Major Depressive Disorder

The effects of psilocybin are thought to be mediated by its ability to promote neuroplasticity and enhance emotional processing.

Benefits of Psilocybin Therapy

  • Rapid Onset: Produce rapid and sustained antidepressant effects. Some individuals experience improvements after just a single dose.
  • Long-lasting Effects: Can persist for months or even years after treatment.
  • Enhanced Emotional Processing: Psilocybin appears to facilitate emotional breakthroughs and insights. This allows patients to confront and resolve underlying issues contributing to their depression.
  • Reduced Suicidal Ideation: Preliminary evidence suggests that psilocybin therapy may help reduce suicidal thoughts and behaviours in individuals with treatment-resistant depression.

Risks and Considerations

While psilocybin therapy shows a good effect as a treatment for Major Depressive Disorder, it is not without risks. Some potential considerations include:

  • Psychological Effects: Psilocybin can induce intense psychedelic experiences, which may be unsettling or overwhelming for some individuals.
  • Safety Concerns: Although psilocybin is commonly well-tolerated, there’s a risk of adverse reactions. This can cause paranoia and psychosis, particularly in susceptible individuals.

Experiment With the Best Psilocybin Products

Few clinical trials are currently underway to investigate the safety of psilocybin therapy for Major Depressive Disorder. These studies evaluate various treatment aspects, including optimal dosing regimens, therapeutic protocols, and long-term outcomes. 

Initial findings have been promising, with many participants reporting significant improvements in mood and quality of life.

What are the best psilocybin products at a ‘mushroom dispensary near me’ you should try? Check the top picks below:


Boost your immune system with the microdosing blend of Golden Teacher Psilocybe and other organic mushrooms. These non-psychoactive mushrooms contain natural compounds like polysaccharides, terpenoids, sterols, and lipids. 

Studies suggest they have benefits, including lowering cholesterol, reducing inflammation, and potentially fighting cancer. They can also help regulate your immune system if you’re fighting off an infection or calming it down during allergies or autoimmune reactions.

2.Mastermind – Snore Lax Capsules

Mastermind presents Snore Lax Capsules, each containing 200mg, sold in packs of 15. These capsules aim to support better sleep and reduce waking up during the night. The mix of ingredients signals your body to sleep, converting it into serotonin.

Ingredients include Psilocybin Mushrooms, Melatonin, Ashwagandha, and Magnesium. It contains Psilocybin Mushrooms and should be kept away from children and pets and stored safely.

For first-time users, take one 200mg capsule. Wait for 30-60 minutes for full effect before considering another dose.

3.Ground Sounds – Microdose Capsules – Super Freak

This blend includes potent adaptogens known for reducing stress and inflammation while improving the immune system, energy, and strength. It’s now available in three doses: a low dose of 50mg pure psilocybin per capsule or higher doses of 100mg or 250mg to make you feel super healthy.

How to Consume Psilocybin Products Effectively?


Make sure you take the right amount of psilocybin. This can change depending on things like how sensitive you are, how much you weigh, and if you’ve used psychedelics before. In hospitals, doctors measure and give out the right doses. If you’re taking it yourself, start with a small amount and slowly take more to avoid having a bad experience.

Set and Setting

Where you are and how you feel play a big part in how psilocybin affects you. It’s best to be in a safe, cozy place without anything stressful around. Pick a quiet spot you know well, make sure you’re comfy (like having a nice chair and good lighting), and maybe have a friend with you.


Before trying psilocybin, it’s smart to check your health and mental state to see if it’s safe for you. This helps figure out if you might have any problems from using it, like if you have health issues, mental health conditions, or if you’re taking other medications that might not mix well with psilocybin.

There’s More Beyond the Future of Psilocybin

The study on psilocybin’s efficacy in treating Major Depressive Disorder represents a significant step forward in mental health research. While more studies are needed to understand its potential fully, the findings offer hope for those who have struggled to find relief from depression through traditional means.

Frequently Asked Questions

Is Psilocybin therapy a standalone treatment for MDD?

Psilocybin therapy is used as part of a comprehensive treatment approach for MDD. This may include psychotherapy, medication, lifestyle modifications, and other interventions. Its effect may vary depending on individual factors. 

How long does Psilocybin therapy last for MDD?

Psilocybin therapy sessions go on for quite a few hours, usually around 6 to 8 hours. This time is needed to feel the effects of the psychedelic shroom fully and to talk about the experience afterward.

How long do Psilocybin therapy’s effects last for MDD?

Even though the strong effects of Psilocybin only last a few hours, its positive effects can last much longer. Many people say they feel better for weeks or even months after just one session of Psilocybin therapy, especially if they also talk about the experience with a therapist and have more sessions later on.

Are there any things to be careful about before Psilocybin therapy for MDD?

People who’ve had psychosis before, some mental health conditions, or heart problems might not be good candidates for Psilocybin therapy. Also, if you’re pregnant or breastfeeding, it’s safer not to use Psilocybin because it could harm the baby. Inform your doctor about any medicines or supplements you’re taking to ensure they won’t cause problems with Psilocybin.

Any tips for getting ready before Psilocybin therapy for MDD?

Before Psilocybin therapy, it’s best to avoid alcohol and recreational drugs to make sure it’s safe and work well. Also, try to live healthily by sleeping enough, eating well, and doing things like meditation or relaxation exercises, which can improve the therapy.

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